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Hace 5 días · Dr. David Baker is Professor of Biochemistry; Adjunct Professor of Genome Sciences, Bioengineering, Chemical Engineering, Computer Science, and Physics; and Head of the Institute for Protein Design at the University of Washington. He is also an Investigator of the Howard Hughes Medical Institute.
10 de jun. de 2024 · Summary. Many growth factors and cytokines signal by binding to the extracellular domains of their receptors and driving association and transphosphorylation of the receptor intracellular tyrosine kinase domains, initiating downstream signaling cascades.
10 de jun. de 2024 · We evaluated the receptor isoform specificity of our synthetic agonists by treating serum-starved L6 rat myoblast cells stably expressing either the c- or b-isoform of hFGFR1 (L6-R1c or L6-R1b, respectively; overexpression was validated with RT-qPCR ) with 10 nM of mb7, FGF2, or C6-79C_mb7 for 15 min at 37°C.
23 de jun. de 2024 · Abstract. Interleukin (IL)-23 and IL-17 are well-validated therapeutic targets in autoinflammatory diseases. Antibodies targeting IL-23 and IL-17 have shown clinical efficacy but are limited by high costs, safety risks, lack of sustained efficacy, and poor patient convenience as they require parenteral administration.
10 de jun. de 2024 · This will help scientists understand biology and ultimately prevent and repair disease,” said senior author David Baker, a Howard Hughes Medical Institute Investigator, professor of biochemistry, and director of the Institute for Protein Design at the University of Washington School of Medicine.
10 de jun. de 2024 · “Computer vision is rapidly advancing thanks to work in both industry and academia,” said David Crandall, Professor of Computer Science at Indiana University, Bloomington, Ind., U.S.A., and CVPR 2024 Program Co-Chair.
Hace 3 días · Protein design pioneer David Baker on why sharing code is key to building biotech startups – AI Briefing | The best news about artificial intelligence. AI2 Incubator’s Jenny Cronin (left), interviews David Baker, director of the University of Washington’s Institute for Protein Design. (GeekWire Photo / Charlotte Schubert) The Institute for Protein.
