Resultado de búsqueda
Hace 3 días · Furthermore, Adaptive Poisson-Boltzmann Solver (APBS) analysis of the electrostatic surface potential shows a high negative charged area (red) on vinculin between S1 and S2 and, a low electron ...
Hace 5 días · SMARCAL1 downregulation led toward the increased localization of PML (promyelocytic leukemia) bodies in ALT telomeres and triggered the formation of APBs (ALT-associated promyelocytic leukemia bodies) in ALT positive cell lines, increasing telomere replication stress and DNA damage at a genomic level.
Hace 5 días · Credit in Lieu of Standard Training for Internal Medicine Candidates. Certification Using the Research Pathway. Exam policy information for Internal Medicine.
Hace 5 días · Most of the human cancers are dependent on telomerase to extend the telomeres. But ∼10% of all cancers use a telomerase-independent, homologous recombination mediated pathway called alternative lengthening of telomeres (ALT). Due to the poor prognosis, ALT status is not being considered yet in the diagnosis of cancer. No such specific treatment is available to date for ALT positive cancers ...
Hace 12 horas · Mitogen-activated protein kinase kinase 1 (MAPK kinase 1, MEK1) is a key kinase in the mitogen-activated protein kinase (MAPK) signaling pathway. MEK1 mutations have been reported to lead to abnormal activation that is closely related to the malignant growth and spread of various tumors, making it an important target for cancer treatment. Targeting MEK1, four small-molecular drugs have been ...
Hace 3 días · The B. napus GL3 protein encoded by the B. napus DH12075 is a doubled haploid, semi-glabrous line derived from a cross between the French cultivar Cresor and the Canadian cultivar Westar. The A-genome homeologue (BnaN04g12460) of DH12075 was identical to that of Westar and 99.52–100% identical to those from lines of B. rapa (A-genome). The B. napus DH12075 and B. rapa CN30467 (moderately ...
Hace 2 días · Från söndag morgon är det en gul varning för vind för nordvästra Götaland och sydvästra Svealand. Västtrafik ställer in vissa tåglinjer som ersätts med bussar. Polisen varnar för ...
