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19 de ene. de 2023 · Asthma is characterised by intermittent and variable symptoms of bronchospasm and airway inflammation (ie, dyspnoea, tightness of the chest, wheezing, cough, and phlegm), which occur either spontaneously or in response to triggers such as exercise or cold air.
Asthma is a consequence of complex gene–environment interactions, with heterogeneity in clinical presentation and the type and intensity of airway inflammation and remodelling. The goal of asthma treatment is to achieve good asthma control—ie, to minimise symptom burden and risk of exacerbations.
19 de ene. de 2023 · Patients with severe asthma often have co-existing conditions contributing to their symptoms, mandating a multidimensional management approach. In this Seminar, we provide a clinically focused overview of asthma; epidemiology, pathophysiology, diagnosis, and management in children and adults.
24 de feb. de 2018 · In this Seminar, we provide a clinically focused overview of asthma, including epidemiology, pathophysiology, clinical diagnosis, asthma phenotypes, severe asthma, acute exacerbations, and clinical management of disease in adults and children older than 5 years.
23 de ene. de 2023 · Patients with severe asthma often have co-existing conditions contributing to their symptoms, mandating a multidimensional management approach. In this Seminar, we provide a clinically focused overview of asthma; epidemiology, pathophysiology, diagnosis, and management in children and adults.
Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial. Lancet Respir Med. 2021 Jan;9 (1):69-84. doi: 10.1016/S2213-2600 (20)30389-1. Epub 2020 Sep 9. Authors.
The current international and national guidelines for the treatment of acute asthma seem entirely appropriate in recommending high-dose inhaled β 2-agonist in conjunction with systemic corticosteroid, and reserving second-line therapy with ipratropium bromide or intravenous bronchodilators for refractory or more severe cases.
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