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26 de may. de 2015 · Cross-electrophile coupling, the cross-coupling of two different electrophiles, avoids the need for preformed carbon nucleophiles, but development of general methods has lagged behind cross-coupling and C–H functionalization.
6 de dic. de 2021 · Electrochemical catalytic reductive cross couplings are powerful and sustainable methods to construct C−C bonds by using electron as the clean reductant.
13 de may. de 2014 · Reductive cross-electrophile coupling reactions have recently been developed to a versatile and sustainable synthetic tool for selective C C bond formation. The employment of cheap and abundant electrophiles avoids the pre-formation and handling of organometallic reagents.
16 de dic. de 2008 · We demonstrate (1) reaction of α-C−H bonds of nitrogen in amines, (2) reaction of α-C−H bonds of oxygen in ethers, (3) reaction of allylic and benzylic C−H bonds, and (4) reaction of alkane C−H bonds. These CDC reactions can tolerate a variety of functional groups, and some can occur under aqueous conditions.
Hace 5 días · Conspectus. In recent years, nickel-catalyzed asymmetric coupling reactions have emerged as efficient methods for constructing chiral C(sp 3) carbon centers.Numerous novel approaches have been reported to rapidly construct chiral carbon–carbon bonds through nickel-catalyzed asymmetric couplings between electrophiles and nucleophiles or asymmetric reductive cross-couplings of two different ...
Comprehensive Summary. Constructing C—C bonds is central to the synthesis of all chemical products. While conventional C—C bond formation methods always require one or two functional groups, 20 years ago, our establishment of the concept of Cross-Dehydrogenative Coupling (CDC), wherein C—C bonds are directly formed from two different C ...
14 de dic. de 2012 · The Sonogashira–Hagihara coupling has become arguably the most useful method for preparing natural products, agrochemicals, pharmaceuticals, and conjugated polymers through the coupling of terminal alkynes and sp 2-hybridized carbons (e.g., aryl, heteroaryl, and alkenyl halides).
