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  1. As soon as the dog was freed, he “appear’d…stupifi’d” and crumpled to the floor, having become the recipient of the world’s first intravenous anesthetic. Wren and Willis would later use intravascular injections to delineate yet another famed anatomic circuit—the brain’s arterial “Circle of Willis.” (Copyright © the American ...

  2. I read with great interest the note on Anesthesiology Reflections by Bause, 1 where he writes that in 1659 the future Sir Christopher Wren and Robert Boyle pioneered intravenous therapy, adding that by November 1660 both were meeting with 10 other scientists; gatherings that would lead to the formal chartering of the Royal Society of London for ...

  3. Intravenous (IV) anesthesia and analgesia began in 1656 with the English architect and founder of the Royal Society, Christopher Wren (1632–1723).

  4. Sir Christopher Wren used a syringe made of animal bladder fixed to a goose quill to inject wine and opium into the veins of dogs. J.D. Major from Kiel and J.S. Elsholtz from Berlin probably were the first to deliberately administer intravenous injections to people in the 1660s.

  5. Las primeras inyecciones de sustancias por esta vía, realizadas con fines experimentales y no terapéuticos, se deben a Christopher Wren (1632-1723), el célebre arquitecto, que inyectó en 1656 vino y cerveza en las venas de un perro.

  6. 1 de ene. de 2013 · The constraint for the earliest date would appear to be Boyle's move to Oxford leading soon to his conversation with John Wilkins and Christopher Wren at which Wren explained that ‘he thought he could easily contrive a way to convey any liquid poison immediately into the mass of blood'. 8 Frank suggests a date of ‘about March ...

  7. Las primeras inyecciones de sustancias por esta vía, reali-zadas con fines experimentales y no terapéuticos, se deben a Christopher Wren, que en 1956, con la ayuda de una veji-ga de cerdo como recipiente y una pluma de ganso como aguja, logró introducir cerveza y vino en la vena de un perro.