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La familia Rho de las GTPasas es una familia de pequeñas (~21 kDa) proteínas G de señalización, y es una superfamilia de las Ras. Se ha demostrado que los miembros de la familia GTPasa Rho regulan muchos aspectos de la dinámica intracelular en la actina y están en todos los reinos eucariotas, incluidas las levaduras y algunas plantas. Se han estudiado en detalle tres miembros de esta ...
5 de feb. de 2021 · Ras homology (RHO) GTPases are signalling proteins that have crucial roles in triggering multiple immune functions. Through their interactions with a broad range of effectors and kinases, they...
At least three striking features have emerged from the analysis of Ras and Rho GTPases: (1) the diversity of membrane receptors and upstream regulators that can activate these GTPases, (2) the diversity of cellular targets that can interact with an individual GTPase, and (3) the extensive cross-talk and cooperation that exists between GTPase-reg...
20 de jul. de 2021 · The molecular mechanisms of RHO GTPase regulation have been well characterized, but our understanding of the signal transduction to downstream targets and, most notably, the autoinhibitory mechanisms of GEFs, GAPs, and effectors remain unclear.
23 de may. de 2023 · Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular switches in regulating key cellular functions. Their dysregulation is a therapeutic target for tumors ...
2 de ago. de 2022 · Rac1 is a ubiquitous and highly conserved Rho GTPase across species that modulates numerous cellular functions that are essential for normal development.
Hace 1 día · Initially described as RHO-like, MIRO GTPases cluster by sequence similarity between the RAS and RHO subfamilies but lack the RHO helical insert. They are tethered to mitochondria and comprise two GTPase domains, one N-terminal (nGTPase) and another C-terminal (cGTPase), separated by a pair of calcium-binding EF-hands (Klosowiak et al, 2013 ).
