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  1. Russell and Burch's The Principles of Humane Experimental Technique was first published in 1959. A Special Edition containing the original text was reissued in 1992, after its ideas had gained widespread interest in the scientific community. In the Principles, Russell and Burch proposed a new applie …

  2. Neste documento, uma reinterpretação dos 3Rs (3Rs) propostos por William Russell e Rex Burch (Substituição, Redução e Refinamento) será realizada com o objetivo de ampliar seu escopo e melhorar as práticas não-humanas de testes em animais. ... Russell, William y Rex Buch. 1959.

  3. 30 de mar. de 2023 · Propósito/Contexto. En el presente trabajo se llevará a cabo una reinterpretación de las tres erres (3R) propuestas por William Russell y Rex Burch (reemplazo, reducción y refinamiento), con ...

  4. 30 de ago. de 2023 · In 1959, the British scientists William Russel and Rex Burch published the 3R principle as a doctrine for experimental scientific work in their book The Principles of Humane Experimental Technique.. The goal of the 3R principle is to completely avoid animal experiments (replacement), minimize the number of animals (reduction), and limit their suffering in experiments to an absolute minimum ...

  5. In 1959, William Russell and Rex Burch published "The Principles of Humane Experimental Technique". They proposed that if animals were to be used in experiments, every effort should be made to Replace them with non-sentient alternatives, to Reduce to a minimum the number of animals used, and to Refine experiments which used animals so that they caused the minimum pain and distress.

  6. ción de las tres erres (3R) propuestas por William Russell y Rex Burch (reemplazo, reducción y refinamiento), con el objetivo de ampliar su alcance y mejorar las prácticas de experimentación con animales no humanos. Metodología/Enfoque. Se revisará el sentido que le dieron Russell y Burch a las 3R y se evaluará el modo en que cada una de ...

  7. The Scope of Humane Technique: Table of Contents; Foreword to Special Edition; Preface; Scope of the Study; Integration in the Vertebrate Organism; Pain and Distress